10x Genomics Partners On Global AI Biology Atlas Initiative

Bioptimus, a global AI company building the world's first world model for biology, today announced the launch of its Spatial Tissue Embedding Learning Atlas (STELA), a multinational spatial data generation initiative anchored by a partnership with 10x Genomics, Inc. (NASDAQ:TXG) and Broad Clinical Labs.

While foundation models for language have thrived on vast digital datasets, biology has long lacked the standardized, high-quality data scale required for a similar breakthrough, particularly for clinical data; Bioptimus is closing this gap by building the data infrastructure necessary to power M-Optimus, the first multimodal and multiscale world model of biology. STELA will serve as the data backbone for M-Optimus, generating massive datasets designed to decrypt the complex organization of human tissues. M-Optimus will leverage this massive multimodal repository to map how molecular and cellular interactions drive disease in fields like oncology and inflammation, ultimately allowing researchers to anticipate patient responses to novel therapies, accelerate drug development, and design more effective immunotherapies.

Starting with 10x Genomics'' Xenium spatial transcriptomics and designed to integrate additional spatial and molecular profiling technologies over time, STELA will generate harmonized datasets, integrating: high-resolution spatial transcriptomics, matched histopathology imaging, multi-omics data (e.g., genomics, transcriptomics and proteomics), with longitudinal clinical records. The initiative aims to profile up to 100,000 patient tissue specimens across three continents: the United States, Europe, and Asia, establishing the world's largest clinically linked, spatially profiled, multimodal patient data atlas.

Participating hospitals and research institutions will contribute samples under standardized protocols and, in return, receive access to rich spatial characterization and foundation model capabilities. This collaboration empowers clinicians to turn raw data into actionable insights through more precise diagnostic and therapeutic strategies. By aligning data generation protocols, data processing and storage, and AI model development within a unified framework at a diverse, global scale, STELA establishes foundational infrastructure for the next era of biological AI.